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Gut bacteria degrade purines <i>via</i> the 2,8-dioxopurine pathway

2025-04-25

Abstract excerpt

The loss of uricase during hominid evolution has predisposed humans to hyperuricemia and gout, conditions with high global prevalence. In healthy individuals, approximately one-third of urate is excreted into the intestinal tract 1 where bacteria consume this purine aiding in its elimination 2,3 . However, the molecular details of purine metabolism in the gut microbiome remain unknown. Here we uncover the 2,8-di...

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Identifiers and source

Literature Corpus work
4dd08a78-4c21-52ae-b114-dd8fe3d71ab6
DOI
10.1101/2025.04.24.650524
Open publication

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