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A Reductive Uric Acid Degradation Pathway in Anaerobic Bacteria

2025-05-20

Abstract excerpt

Uric acid is a key intermediate in purine degradation across diverse organisms, while its accumulation in humans leads to inflammation and gout disease. Aerobic organisms degrade uric acid via a well-known “oxidative pathway” involving dearomatization of the purine core catalyzed by uric acid oxidases or dehydrogenases. The ability to degrade uric acid is also widespread in anaerobic bacteria, including gut bacter...

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Literature Corpus work
58fce12f-c66b-593b-a027-83209f9b8689
DOI
10.1101/2025.05.19.654654
Open publication

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A Reductive Uric Acid Degradation Pathway in Anaerobic BacteriaDOI 10.1101/2025.05.19.654654
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