Article

Selective Sugar Transport Supports <i>Proteus mirabilis</i> Fitness in the Urinary Tract

2026-02-21

Abstract excerpt

<h4>ABSTRACT</h4> Proteus mirabilis is a leading cause of complicated urinary tract infections (UTIs). Prior work showed P. mirabilis metabolizes sugars during experimental UTI, yet the role of sugar import systems in pathogenesis remains poorly defined. To investigate this, we generated a panel of 47 targeted mutants in predicted sugar transporter genes and assessed their growth in vitro and fitness in vivo ....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cafd47b5-5088-5ce2-b241-241e93017cc3
DOI: 10.64898/2026.02.20.707088

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Selective Sugar Transport Supports <i>Proteus mirabilis</i> Fitness in the Urinary TractDOI 10.64898/2026.02.20.707088Read

Preferential catabolism of L- vs D-serine by <i>Proteus mirabilis</i> contributes to pathogenesis and catheter-associated urinary tract infectionSemantic proximity Read

Genome-wide transposon mutagenesis of Proteus mirabilis: Essential genes, fitness factors for catheter-associated urinary tract infection, and the impact of polymicrobial infection on fitness requirementsSemantic proximity Read

The <i>Streptococcus pyogenes</i> mannose phosphotransferase system (Man-PTS) influences antimicrobial activity and niche-specific nasopharyngeal infectionSemantic proximity Read

Preferential Use of Central Metabolism In Vivo Reveals a Nutritional Basis for Polymicrobial InfectionSemantic proximity Read

Identification of virulence determinants in uropathogenic Proteus mirabilis using signature-tagged mutagenesis.Semantic proximity Read

Transposon Insertion Site Sequencing of Providencia stuartii: Essential Genes, Fitness Factors for Catheter-Associated Urinary Tract Infection, and the Impact of Polymicrobial Infection on Fitness Requirements.Semantic proximity Read

Metabolomics survey of uropathogenic bacteria in human urineSemantic proximity Read

Proteus mirabilis genes that contribute to pathogenesis of urinary tract infection: identification of 25 signature-tagged mutants attenuated at least 100-fold.Semantic proximity Read

Contribution of Three tRNA Modification Enzymes to <i>Proteus mirabilis</i> Fitness and Catheter-Associated Urinary Tract InfectionSemantic proximity Read

Capsule Production and Glucose Metabolism Dictate Fitness during Serratia marcescens BacteremiaSemantic proximity Read

Gut bacteria degrade purines <i>via</i> the 2,8-dioxopurine pathwaySemantic proximity Read

Purine and carbohydrate availability drive <i>Enterococcus faecalis</i> fitness during wound infectionSemantic proximity Read