A reductive uric acid degradation pathway in anaerobic bacteria

Abstract excerpt

Abstract Uric acid (UA) is a key intermediate in purine degradation across diverse organisms, while its accumulation in humans leads to inflammation and gout disease. Aerobic organisms degrade UA via a well-known “oxidative pathway” involving dearomatization of the purine core catalyzed by UA oxidases or dehydrogenases. The ability to degrade UA is also widespread in anaerobic bacteria, including gut bacteria,...

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