Article

DNA-utilization loci enable exogenous DNA metabolism in gut Bacteroidales

2025-03-18

Abstract excerpt

<h4>ABSTRACT</h4> The human gut microbiome plays a central role in nutrient metabolism, yet the fate of exogenous nucleic acids within this ecosystem remains poorly understood. Here, we show that multiple Bacteroidales species efficiently metabolize exogenous DNA, with Bacteroides thetaiotaomicron converting it into the deaminated nucleobases uracil and xanthine. Using genetic and biochemical approaches, we iden...

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Literature Corpus work: 111413a3-4594-5774-837c-7956273cc7e3
DOI: 10.1101/2025.03.18.642099

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