Article

A widely distributed gene cluster compensates for uricase loss in hominids

2022-07-25

Abstract excerpt

<h4>Summary</h4> Approximately 15% of US adults have circulating levels of uric acid above its solubility limit, which is causally linked to the disease gout. In most mammals, uric acid elimination is facilitated by the enzyme uricase. However, human uricase is a pseudogene, having been inactivated early in hominid evolution. Though it has long been known that uric acid is eliminated in the gut, the role of the g...

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Identifiers and source

Literature Corpus work: 2cbe7b50-239a-5e8c-9bb8-8b9868810488
DOI: 10.1101/2022.07.24.501321

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