Article

Periplasmic detoxification of urate hydroperoxide underpins <i>E. coli</i> survival in the inflamed gut

2026-06-02

Abstract excerpt

<h4>ABSTRACT</h4> Uric acid, the final product of purine metabolism in humans, accumulates in blood and tissues at relatively high concentrations 1 as humans lack the enzyme uricase 2,3 . Under inflammatory conditions, uric acid can be oxidised to yield reactive intermediates 4 . In activated neutrophils, myeloperoxidase (MPO) catalyses the oxidation of uric acid by hydrogen peroxide, leading to the formation...

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Literature Corpus work: bd99c64f-4745-5354-a9bc-55de8e12c62a
DOI: 10.64898/2026.06.01.729251

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