Article

Dual quorum-sensing control of purine biosynthesis drives pathogenic fitness of <i>Enterococcus faecalis</i>

2024-08-13

Abstract excerpt

<h4>ABSTRACT</h4> Enterococcus faecalis is a resident of the human gut, though upon translocation to the blood or body tissues, it can be pathogenic. Here we discover and characterize two peptide-based quorum-sensing systems that transcriptionally modulate de novo purine biosynthesis in E. faecalis . Using a comparative genomic analysis, we find that most enterococcal species do not encode this system; E. morav...

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Literature Corpus work: 6facb35f-b953-5d9b-b579-a5ecfc63c8e4
DOI: 10.1101/2024.08.13.607696

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