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Machine learning identifies T cell receptor repertoire signatures associated with COVID-19 severity

20 Jan 2023

Abstract excerpt

T cell receptor (TCR) repertoires are critical for antiviral immunity. Determining the TCR repertoire composition, diversity, and dynamics and how they change during viral infection can inform the molecular specificity of host responses to viruses such as SARS-CoV-2. To determine signatures associated with COVID-19 disease severity, here we perform a large-scale analysis of over 4.7 billion sequences across 2130...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36670287
DOI: 10.1038/s42003-023-04447-4

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