Article

A kinase-independent function of cyclin-dependent kinase 6 promotes outer radial glia expansion and neocortical folding

2022-05-25

Abstract excerpt

The neocortex, the center for higher brain function, first emerged in mammals and has become massively expanded and folded in humans, constituting almost half the volume of the human brain. Primary microcephaly, a developmental disorder in which the brain is smaller than normal at birth, mainly results from the number of neurons in the neocortex being reduced because of defects in neural progenitor cells (NPCs). O...

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Literature Corpus work: afae503b-a4e0-5277-be45-53e59c4bad07
DOI: 10.1101/2022.05.24.493266

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