Article

Mutant FGFR3 restricts bone yet expands cortex via ERK-mediated self-repression

2026-02-06

Abstract excerpt

<h4>Summary</h4> FGFR3 gain-of-function mutations cause achondroplasia 1,2 , the most common form of dwarfism, yet trigger paradoxical cerebral overgrowth and skeletal stunting 3–9 . Here, we demonstrate that Fgfr3-K644E mutant drives enhanced ERK activation, which then represses Fgfr3 expression and downregulates ERK signaling. In the developing cortex, this mechanism transiently expands cortical stem cells...

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Literature Corpus work: 0e02d79b-9e08-5959-8e02-f961bd24440c
DOI: 10.64898/2026.02.03.703675

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