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Article

RAS/ERK Signaling Controls Proneural Genetic Programs in Cortical Development and Gliomagenesis

5 Feb 2014

Abstract excerpt

Neural cell fate specification is well understood in the embryonic cerebral cortex, where the proneural genes Neurog2 and Ascl1 are key cell fate determinants. What is less well understood is how cellular diversity is generated in brain tumors. Gliomas and glioneuronal tumors, which are often localized in the cerebrum, are both characterized by a neoplastic glial component, but glioneuronal tumors also have an...

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PMID: 24501358
DOI: 10.1523/jneurosci.4077-13.2014

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