Article

OGT ( <i>O</i> -GlcNAc Transferase) selectively modifies multiple residues unique to lamin A

2017-10-26

Abstract excerpt

The LMNA gene encodes lamins A and C with key roles in nuclear structure, signaling, chromatin organization, and genome integrity. Mutations in LMNA cause >12 diseases, termed laminopathies. Lamins A and C are identical for their first 566 residues. However, they form distinct filaments in vivo with apparently distinct roles. We report that lamin A is O -GlcNAc modified in human hepatoma (Huh7) cells and in mo...

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Literature Corpus work: 4d9ae547-e3e8-5a32-baba-5572347cffc8
DOI: 10.1101/206458

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