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Article

Systematic mapping of O-GlcNAc transferase and O-GlcNAcase defines disease-associated variants.

The Journal of biological chemistry - 1 Jun 2026

Kimi Jonah, Malard Florian, Olivier-Van Stichelen Stephanie

Abstract excerpt

For decades, O-GlcNAcylation has been recognized as a critical posttranslational modification involved in numerous physiological processes and increasingly implicated in human disease. Despite substantial evidence linking O-GlcNAcylation to neurodegeneration and cancer, O-GlcNAc cycling enzymes were long considered so essential that any meaningful amino acid substitution would not be tolerated in humans. However,...

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Identifiers

PMID: 42107645
DOI: 10.1016/j.jbc.2026.113134
PMCID: PMC13264370

Genes

OGT
OGA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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