Tet3 Mediates O-GlcNAcylation-Induced Remyelination

Abstract excerpt

<h4>ABSTRACT</h4> The failure of oligodendrocyte precursor cells (OPCs) to generate mature oligodendrocytes represents a major hurdle impeding myelin repair. However, the cellular determinants for OPC differentiation and the pharmacological targets driving remyelination remain rudimentary. Here, we demonstrate that O-GlcNAcylation intrinsically drives remyelination, in which Tet3 is one downstream effector. Enhan...

Topics

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• Acetylglucosamine
• Glycosylation
• Intellectual Disability
• Mice
• Mutation
• N-Acetylglucosaminyltransferases
• Protein Processing, Post-Translational
• Signal Transduction

Identifiers and source

Literature Corpus work

3bce6442-2e92-56f2-b7ac-17553f0cdebd

DOI

10.1101/2025.01.24.634702