Article

Cancer-derived mutation in the OGA stalk domain promotes cell malignancy through dysregulating PDLIM7 and p53

2023-03-20

Abstract excerpt

<title>Abstract</title> <p>O-GlcNAcase (OGA) is the sole enzyme that hydrolyzes O-GlcNAcylation from thousands of proteins and is dysregulated in many diseases including cancer. However, the substrate recognition and pathogenic mechanisms of OGA remain largely unknown. Here we report the first discovery of a cancer-derived point mutation on the OGA’s non-catalytic stalk domain that aberrantly regulated a small se...

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Literature Corpus work: ff5e59e2-0de3-51f1-ba23-4fe0b2758fc5
DOI: 10.21203/rs.3.rs-2709128/v1

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