Article

Rational antigen engineering and mucosal delivery design for next-generation RSV vaccines

2026-07-28

Abstract excerpt

Respiratory syncytial virus (RSV) prefusion F (preF) vaccines have transformed adult prophylaxis, yet unmet needs in antigen stability, pediatric safety, and mucosal protection persist. Here, we develop an integrated structure-guided RSV vaccine design platform that couples allosteric stabilization, epitope-focused immunogen engineering, and route-specific mRNA delivery for systemic and mucosal immune activations....

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Literature Corpus work: 4d738f82-d3f6-505a-9244-097ac353ff53
DOI: 10.64898/2026.07.28.739720

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