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Design and preclinical assessment of mRNA-1345 prefusion F glycoprotein-encoding mRNA vaccine for respiratory syncytial virus

20 Aug 2025

Abstract excerpt

Respiratory syncytial virus (RSV) is a significant cause of lower respiratory tract disease in young children and older adults. We designed a codon-optimized mRNA vaccine, mRNA-1345, encoding the RSV F-glycoprotein stabilized in the prefusion (preF) conformation and with a deletion at the cytoplasmic tail. mRNA-1345 cell surface protein expression was higher and detected for longer versus previous mRNA-based RSV...

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PMID: 40840264
DOI: 10.1016/j.vaccine.2025.127589

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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