Article

A Safe and Effective Mucosal RSV Vaccine Consisting of RSV Phosphoprotein and Flagellin Variant

2021-02-10

Abstract excerpt

<h4>SUMMARY</h4> Respiratory syncytial virus (RSV) is a major cause of serious acute lower respiratory tract infection in infants and the elderly. No licensed RSV vaccine available thus far calls for the development of vaccines with new target(s) and vaccination strategies. Here, we constructed a recombinant protein, designated P-KFD1, comprised of RSV phosphoprotein (P) and E. coli K12 strain-derived flagellin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 27b0c27f-100b-599f-989f-68fd1f2cc836
DOI: 10.1101/2021.02.09.430425

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Safe and Effective Mucosal RSV Vaccine Consisting of RSV Phosphoprotein and Flagellin VariantDOI 10.1101/2021.02.09.430425Read

A safe and effective mucosal RSV vaccine in mice consisting of RSV phosphoprotein and flagellin variant.Semantic proximity Read

Biology of Infection and Disease Pathogenesis to Guide RSV Vaccine DevelopmentSemantic proximity Read

New mucosal bivalent live-attenuated vaccine is protective against Human Metapneumovirus and Respiratory Syncytial VirusSemantic proximity Read

Multiepitope-Based Subunit Vaccine Design and Evaluation against Respiratory Syncytial Virus Using Reverse Vaccinology ApproachSemantic proximity Read

RSV--a substantial slice of the airway disease burden and the way to a vaccine.Semantic proximity Read

Designing of Potential Polyvalent Vaccine Model for Respiratory Syncytial Virus by System Level Immunoinformatics Approaches.Semantic proximity Read

A Pan-Pneumovirus vaccine based on immunodominant epitopes of the fusion proteinSemantic proximity Read

Rational antigen engineering and mucosal delivery design for next-generation RSV vaccinesSemantic proximity Read

A conserved antigen induces respiratory Th17-mediated serotype-independent protection against pneumococcal superinfectionSemantic proximity Read

Robust and Long-Lasting Immunity and Protection in Mice Induced by Lipopolyplex-Delivered mRNA Vaccines Expressing the Prefusion Protein of Respiratory Syncytial VirusSemantic proximity Read

Kinetically activating nanovaccine mimicking multidimensional immunomodulation of natural infection for broad protection against heterologous viruses in animal modelsSemantic proximity Read

A Highly Immunogenic Measles Virus-based Th1-biased COVID-19 VaccineSemantic proximity Read