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Improved mRNA-based RSV vaccine with PreF forming enveloped virus-like particles

12 Jul 2025

Abstract excerpt

Respiratory syncytial virus (RSV) causes severe respiratory disease in infants and the elderly. However, natural infection fails to induce durable immune protection, and existing mRNA vaccines for older adults exhibit limited long-term efficacy. We developed an antigen engineering strategy inserting ESCRT/ALIX-binding region (EABR) into truncated RSV prefusion F (PreF) cytoplasmic tails to form enveloped...

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PMID: 40651980
DOI: 10.1038/s41541-025-01205-x

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