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A hierarchical activation threshold shapes RSV F antibody repertoires from toddler vulnerability to adult protection

2026-07-29

Abstract excerpt

<h4>Summary</h4> Respiratory syncytial virus (RSV) causes severe infant morbidity, yet the mechanisms underlying their suboptimal immunity and the failure of prefusion F-stabilized adult vaccines in infants remain unclear. Here we integrate deep mutational scanning of 761 preF-binding antibodies, repertoire profiling of 102 repeatedly exposed pediatricians and 61 RSV-experienced toddlers, structural analysis, and...

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Literature Corpus work
8cc97960-16d2-5541-8437-77618b00d7da
DOI
10.64898/2026.07.28.735825
Open publication

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A hierarchical activation threshold shapes RSV F antibody repertoires from toddler vulnerability to adult protectionDOI 10.64898/2026.07.28.735825
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