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Article

Alternative conformations of a major antigenic site on RSV F

15 Jul 2019

Abstract excerpt

The respiratory syncytial virus (RSV) fusion (F) glycoprotein is a major target of neutralizing antibodies arising from natural infection, and antibodies that specifically bind to the prefusion conformation of RSV F generally demonstrate the greatest neutralization potency.Prefusion-stabilized RSV F variants have been engineered as vaccine antigens, but crystal structures of these variants have revealed...

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PMID: 31306469
DOI: 10.1371/journal.ppat.1007944

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