Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus.

doi:10.1038/s41467-024-54287-x

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Article

Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus.

Nature communications - 16 Nov 2024

Lee Yi-Zong, Han Jerome, Zhang Yi-Nan, Ward Garrett, Braz Gomes Keegan, Auclair Sarah, Stanfield Robyn L, He Linling, Wilson Ian A, Zhu Jiang

Abstract excerpt

Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) cause human respiratory diseases and are major targets for vaccine development. In this study, we design uncleaved prefusion-closed (UFC) trimers for the fusion protein (F) of both viruses by examining mutations critical to F metastability. For RSV, we assess four previous prefusion F designs, including the first and second generations of DS-Cav1,...

Topics

Metapneumovirus
Animals
Humans
Respiratory Syncytial Virus, Human
Viral Fusion Proteins
Mice
Antibodies, Neutralizing
Respiratory Syncytial Virus Infections
Female
Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Antibodies, Viral

Crystallography, X-Ray

Viral Vaccines

Mutation

Respiratory Syncytial Virus Vaccines

Paramyxoviridae Infections

Protein Multimerization

Source

Open in PubMed Open full text

Identifiers

PMID: 39550381
DOI: 10.1038/s41467-024-54287-x
PMCID: PMC11569192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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