Article

Phenotype integration improves power and preserves specificity in biobank-based genetic studies of MDD

2022-08-15

Abstract excerpt

Biobanks often contain several phenotypes relevant to a given disorder, and researchers face complex tradeoffs between shallow phenotypes (high sample size, low specificity and sensitivity) and deep phenotypes (low sample size, high specificity and sensitivity). Here, we study an extreme case: Major Depressive Disorder (MDD) in UK Biobank. Previous studies found that shallow and deep MDD phenotypes have qualitativ...

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Literature Corpus work: 4d63b79c-2a37-5ac6-b72e-690c268f4c7f
DOI: 10.1101/2022.08.15.503980

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