Article

Polygenic prediction of major depressive disorder and related traits in African ancestries UK Biobank participants

2023-12-28

Abstract excerpt

<h4>Introduction</h4> Genome-Wide Association Studies (GWAS) over-represent European ancestries compared to the global population, neglecting all other ancestry groups and low-income nations. Consequently, polygenic risk scores (PRS) more accurately predict complex traits in Europeans than African Ancestries groups. Very few studies have looked at the transferability of European-derived PRS for behavioural and men...

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Literature Corpus work: 29c7d1cf-e1b9-5a38-b574-1c893bd8182c
DOI: 10.1101/2023.12.24.23300412

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