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Article

Phenotype integration improves power and preserves specificity in biobank-based genetic studies of major depressive disorder.

Nature genetics - 1 Dec 2023

Dahl Andrew, Thompson Michael, An Ulzee, Krebs Morten, Appadurai Vivek, Border Richard, Bacanu Silviu-Alin, Werge Thomas, Flint Jonathan, Schork Andrew J, Sankararaman Sriram, Kendler Kenneth S, Cai Na

Abstract excerpt

Biobanks often contain several phenotypes relevant to diseases such as major depressive disorder (MDD), with partly distinct genetic architectures. Researchers face complex tradeoffs between shallow (large sample size, low specificity/sensitivity) and deep (small sample size, high specificity/sensitivity) phenotypes, and the optimal choices are often unclear. Here we propose to integrate these phenotypes to...

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Identifiers

PMID: 37985818
DOI: 10.1038/s41588-023-01559-9
PMCID: PMC10703686

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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