Article
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference.
Nature genetics - 1 Feb 2024
Meng Xiangrui, Navoly Georgina, Giannakopoulou Olga, Levey Daniel F, Koller Dora, Pathak Gita A, Koen Nastassja, Lin Kuang, Adams Mark J, Rentería Miguel E, Feng Yanzhe, Gaziano J Michael, Stein Dan J, Zar Heather J, Campbell Megan L, van Heel David A, Trivedi Bhavi, Finer Sarah, McQuillin Andrew, Bass Nick, Chundru V Kartik, Martin Hilary C, Huang Qin Qin, Valkovskaya Maria, Chu Chia-Yi, Kanjira Susan, Kuo Po-Hsiu, Chen Hsi-Chung, Tsai Shih-Jen, Liu Yu-Li, Kendler Kenneth S, Peterson Roseann E, Cai Na, Fang Yu, Sen Srijan, Scott Laura J, Burmeister Margit, Loos Ruth J F, Preuss Michael H, Actkins Ky'Era V, Davis Lea K, Uddin Monica, Wani Agaz H, Wildman Derek E, Aiello Allison E, Ursano Robert J, Kessler Ronald C, Kanai Masahiro, Okada Yukinori, Sakaue Saori, Rabinowitz Jill A, Maher Brion S, Uhl George, Eaton William, Cruz-Fuentes Carlos S, Martinez-Levy Gabriela A, Campos Adrian I, Millwood Iona Y, Chen Zhengming, Li Liming, Wassertheil-Smoller Sylvia, Jiang Yunxuan, Tian Chao, Martin Nicholas G, Mitchell Brittany L, Byrne Enda M, Awasthi Swapnil, Coleman Jonathan R I, Ripke Stephan, Sofer Tamar, Walters Robin G, McIntosh Andrew M, Polimanti Renato, Dunn Erin C, Stein Murray B, Gelernter Joel, Lewis Cathryn M, Kuchenbaecker Karoline
Abstract excerpt
Most genome-wide association studies (GWAS) of major depression (MD) have been conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD, adding data from 21 cohorts with 88,316 MD cases and 902,757 controls to previously reported data. This analysis used a range of measures to define MD and included samples of African (36% of effective sample size), East Asian (26%) and South Asian...
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