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A Combined Pathway and Regional Heritability Analysis Indicates NETRIN1 Pathway Is Associated With Major Depressive Disorder.

Biological psychiatry - 15 Feb 2017

Zeng Yanni, Navarro Pau, Fernandez-Pujals Ana M, Hall Lynsey S, Clarke Toni-Kim, Thomson Pippa A, Smith Blair H, Hocking Lynne J, Padmanabhan Sandosh, Hayward Caroline, MacIntyre Donald J, Wray Naomi R, Deary Ian J, Porteous David J, Haley Chris S, McIntosh Andrew M

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWASs) of major depressive disorder (MDD) have identified few significant associations. Testing the aggregation of genetic variants, in particular biological pathways, may be more powerful. Regional heritability analysis can be used to detect genomic regions that contribute to disease risk. METHODS: We integrated pathway analysis and multilevel regional heritability...

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PMID: 27422368
DOI: 10.1016/j.biopsych.2016.04.017
PMCID: PMC5262437

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PGC

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