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Article

Immune dysregulation accelerates atherosclerosis and modulates plaque composition in systemic lupus erythematosus.

Proceedings of the National Academy of Sciences of the United States of America - 2 May 2006

Stanic Aleksandar K, Stein Charles M, Morgan Adam C, Fazio Sergio, Linton MacRae F, Wakeland Edward K, Olsen Nancy J, Major Amy S

Abstract excerpt

Patients with systemic lupus erythematosus (SLE) have accelerated atherosclerosis. The underlying mechanisms are poorly understood, and investigations have been hampered by the absence of animal models that reflect the human condition of generalized atherosclerosis and lupus. We addressed this problem by transferring lupus susceptibility to low-density lipoprotein (LDL) receptor-deficient (LDLr-/-) mice, an...

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Identifiers

PMID: 16636270
DOI: 10.1073/pnas.0602311103
PMCID: PMC1459011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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