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Article

Do the Apoe-/- and Ldlr-/- Mice Yield the Same Insight on Atherogenesis?

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2016

Getz Godfrey S, Reardon Catherine A

Abstract excerpt

Murine models of atherosclerosis are useful for investigating the environmental and genetic influences on lesion formation and composition. Apoe(-/-) and Ldlr(-/-) mice are the 2 most extensively used models. The models differ in important ways with respect to the precise mechanism by which their absence enhances atherosclerosis, including differences in plasma lipoproteins. The majority of the gene function...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27386935
DOI: 10.1161/ATVBAHA.116.306874
PMCID: PMC5001905

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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