Article

A platform for robust quantitative functional genomics reveals temporal fitness landscapes in African trypanosomes

2026-06-29

Abstract excerpt

Genome-scale phenotypic screening is transforming our understanding of host-pathogen interactions, but accurate quantitation of mutant fitness and generation of libraries in strains that capture complex disease characteristics remains challenging. Here we introduce Direct RNAi Fragment Sequencing (DRiF-Seq), a sequencing-optimized high-throughput RNA-interference platform that enables robust, clone-resolved quanti...

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Literature Corpus work: 4d411c72-26ae-5330-af50-7aff18a0c3e1
DOI: 10.64898/2026.06.27.734978

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