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Article

Deep mutational scanning of the RNase III-like domain in Trypanosoma brucei RNA editing protein KREPB4.

Frontiers in cellular and infection microbiology - 1 Jan 2024

McDermott Suzanne M, Pham Vy, Oliver Brian, Carnes Jason, Sather D Noah, Stuart Kenneth D

Abstract excerpt

Kinetoplastid pathogens including Trypanosoma brucei, T. cruzi, and Leishmania species, are early diverged, eukaryotic, unicellular parasites. Functional understanding of many proteins from these pathogens has been hampered by limited sequence homology to proteins from other model organisms. Here we describe the development of a high-throughput deep mutational scanning approach in T. brucei that facilitates rapid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38650737
DOI: 10.3389/fcimb.2024.1381155
PMCID: PMC11033214

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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