Article
Genome-scale RNA interference profiling of Trypanosoma brucei cell cycle progression defects
10 Sept 2022
Abstract excerpt
Abstract Trypanosomatids, which include major pathogens of humans and livestock, are flagellated protozoa for which cell cycle controls and the underlying mechanisms are not completely understood. Here, we describe a genome-wide RNA-interference library screen for cell cycle defects in Trypanosoma brucei . We induced massive parallel knockdown, sorted the perturbed population using high-throughput flow cytometry,...
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