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RNAi screening identifies Trypanosoma brucei stress response protein kinases required for survival in the mouse

17 Jul 2017

Abstract excerpt

Protein kinases (PKs) are a class of druggable targets in Trypanosoma brucei, the causative agent of Human African Trypanosomiasis (sleeping sickness), yet little is known about which PKs are essential for survival in mammals. A recent kinome-wide RNAi screen with 176 individual bloodstream form Trypanosoma brucei lines identified PKs required for proliferation in culture. In order to assess which PKs are also...

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PMID: 28733613
DOI: 10.1038/s41598-017-06501-8

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