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A <i>Trypanosoma brucei</i> ORFeome-based Gain-of-Function Library identifies genes that promote survival during melarsoprol treatment

2020-07-21

Abstract excerpt

<h4>ABSTRACT</h4> Trypanosoma brucei is an early branching protozoan parasite that causes human and animal African Trypanosomiasis. Forward genetics approaches are powerful tools for uncovering novel aspects of Trypanosomatid biology, pathogenesis, and therapeutic approaches against trypanosomiasis. Here we have generated a T. brucei cloned ORFeome consisting of over 90% of the targeted 7,245 genes and used it t...

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Literature Corpus work
80758ed0-3403-5959-b585-8eb70ed8e0f0
DOI
10.1101/2020.07.19.211375
Open publication

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A <i>Trypanosoma brucei</i> ORFeome-based Gain-of-Function Library identifies genes that promote survival during melarsoprol treatmentDOI 10.1101/2020.07.19.211375
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