Oncogene inactivation-induced senescence facilitates tumor relapse

Abstract excerpt

<h4>ABSTRACT</h4> Oncogene-directed therapies can induce profound tumor regression in oncogene-addicted cancers such as BRAF-mutant melanoma and KRAS-driven pancreatic cancer, but their long-term benefit is often limited by resistance and early relapse. The mechanisms that allow residual cells to adapt, persist in a dormant state, and eventually fuel recurrence remain poorly understood. Here, we show that oncogen...

Topics

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• Carcinogenesis
• Cellular Senescence
• Gene Expression Profiling
• Immunotherapy
• Mitogen-Activated Protein Kinase Kinases
• Oncogenes
• Phenotype
• Telomeres, Telomerase, and Senescence

Identifiers and source

Literature Corpus work

adcd07fc-cf25-524e-b92e-e8cc77012511

DOI

10.1101/2024.07.13.603369