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Exploring Senescence-Related Transcriptional Signatures to Uncover Molecular Subtypes and Key Genes in Hepatocellular Carcinoma

2023-12-19

Abstract excerpt

Hepatocellular carcinoma (HCC) is characterized by uncontrolled cellular proliferation driven by aberrant signal transduction. Cells respond to potential carcinogenic signals by inducing cellular senescence (CS) as a defense mechanism. However, assessing CS levels in various tumors is challenging due to heterogeneity and the lack of universal CS markers. This study integrates single-cell RNA sequencing (scRNA-seq)...

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Literature Corpus work
2e54c8e9-4734-5372-9728-ac5fdc8e1d57
DOI
10.20944/preprints202312.1454.v1
Open publication

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