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Article

Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis.

Nature cell biology - 1 May 2007

Sarkisian Christopher J, Keister Blaine A, Stairs Douglas B, Boxer Robert B, Moody Susan E, Chodosh Lewis A

Abstract excerpt

Activating Ras mutations can induce either proliferation or senescence depending on the cellular context. To determine whether Ras activation has context-dependent effects in the mammary gland, we generated doxycycline-inducible transgenic mice that permit Ras activation to be titrated. Low level...

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Source

Identifiers

PMID: 17450133
DOI: 10.1038/ncb1567

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17450133-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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