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Article

Zebrafish imaging reveals TP53 mutation switching oncogene-induced senescence from suppressor to driver in primary tumorigenesis.

Nature communications - 18 Mar 2022

Haraoka Yukinari, Akieda Yuki, Nagai Yuri, Mogi Chihiro, Ishitani Tohru

Abstract excerpt

Most tumours are thought to arise through oncogenic cell generation followed by additional mutations. How a new oncogenic cell primes tumorigenesis by acquiring additional mutations remains unclear. We show that an additional TP53 mutation stimulates primary tumorigenesis by switching oncogene-induced senescence from a tumour suppressor to a driver. Zebrafish imaging reveals that a newly emerged oncogenic cell...

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Identifiers

PMID: 35304872
DOI: 10.1038/s41467-022-29061-6
PMCID: PMC8933407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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