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The antiviral Interferon pathway drives astrocyte aging and motor decline

2025-11-13

Abstract excerpt

Aging encompasses low-level inflammation and motor decline. Astrocytes are neuroregulatory glial cells that change in aging, particularly in the cerebellum, which is essential for movement coordination. Regulation and functionality of cerebellar astrocytes in aging is unknown. We show that antiviral type I Interferons (IFN-I) drive motor deficits and regional astrocyte aging. Transcriptomics reveal that cerebellar...

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Identifiers and source

Literature Corpus work
4d23b357-d8b4-5371-a849-a29a88454ddf
DOI
10.1101/2025.11.12.688147
Open publication

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The antiviral Interferon pathway drives astrocyte aging and motor declineDOI 10.1101/2025.11.12.688147
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