Article

Targeting UBR5 inhibits postsurgical breast cancer lung metastases by inducing apoptosis mediated by CDC73 and p53

2022-11-28

Abstract excerpt

<h4>Background: </h4> UBR5 is a HECT domain E3 ubiquitin ligase that is frequently amplified in breast, ovarian, and prostate cancers. Heightened UBR5 plays a profound role in promoting tumor growth through immune-dependent mechanisms. However, its mode of action in driving tumor metastasis has not been definitively delineated. <h4>Methods: </h4>: In this study, we used a tetracycline (Tet)-inducible RNAi-mediate...

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Literature Corpus work: 4d20cccc-1c48-5360-a561-7643eb28933b
DOI: 10.21203/rs.3.rs-2288884/v1

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