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Article

WDR5 inhibition halts metastasis dissemination by repressing the mesenchymal phenotype of breast cancer cells.

Breast cancer research : BCR - 21 Nov 2019

Punzi Simona, Balestrieri Chiara, D'Alesio Carolina, Bossi Daniela, Dellino Gaetano Ivan, Gatti Elena, Pruneri Giancarlo, Criscitiello Carmen, Lovati Giulia, Meliksetyan Marine, Carugo Alessandro, Curigliano Giuseppe, Natoli Gioacchino, Pelicci Pier Giuseppe, Lanfrancone Luisa

Abstract excerpt

BACKGROUND: Development of metastases and drug resistance are still a challenge for a successful systemic treatment in breast cancer (BC) patients. One of the mechanisms that confer metastatic properties to the cell relies in the epithelial-to-mesenchymal transition (EMT). Moreover, both EMT and metastasis are partly modulated through epigenetic mechanisms, by repression or induction of specific related genes....

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Source

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Identifiers

PMID: 31752957
DOI: 10.1186/s13058-019-1216-y
PMCID: PMC6873410

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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