Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CCR5 Governs DNA Damage Repair and Breast Cancer Stem Cell Expansion

22 Jan 2018

Abstract excerpt

Abstract The functional significance of the chemokine receptor CCR5 in human breast cancer epithelial cells is poorly understood. Here, we report that CCR5 expression in human breast cancer correlates with poor outcome. CCR5+ breast cancer epithelial cells formed mammospheres and initiated tumors with >60-fold greater efficiency in mice. Reintroduction of CCR5 expression into CCR5-negative breast cancer cells...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Chemokine receptors and signaling
Share to Immunotherapy and Immune Responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29358169
DOI: 10.1158/0008-5472.can-17-0915

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CCR5 Governs DNA Damage Repair and Breast Cancer Stem Cell ExpansionPMID 29358169Read ↗

CXCL1/CXCR2 and CCL5/CCR1/CCR5 Promote Radiation-Induced Reprogramming of Breast Non-cancer Stem Cells into Cancer Stem Cells and Predict Patient Clinical OutcomeSemantic proximity Read ↗

CCR5 is a prognostic biomarker and an immune regulator for triple negative breast cancerSemantic proximity Read ↗

Circulating Tumor Cells in Breast Cancer Patients: A Balancing Act between Stemness, EMT Features and DNA Damage ResponsesSemantic proximity Read ↗

CCR5 Expression Influences the Progression of Human Breast Cancer in a p53-dependent MannerSemantic proximity Read ↗

Molecular Divergence Shapes Lung- and Liver-Tropic Metastasis in HER2-Positive Breast CancerSemantic proximity Read ↗

miR-1275 Targets MDK/AKT Signaling to Inhibit Breast Cancer Chemoresistance by Lessening the Properties of Cancer Stem CellsSemantic proximity Read ↗

Targeting UBR5 inhibits postsurgical breast cancer lung metastases by inducing apoptosis mediated by CDC73 and p53Semantic proximity Read ↗

Targeting MDA5 enhances tumor immunity through immunogenic cell death and augments the efficacy of immune checkpoint blockadeSemantic proximity Read ↗

Differential Regulation of Cancer Progression by CDK4/6 Plays a Central Role in DNA Replication and Repair PathwaysSemantic proximity Read ↗

The C-X-C Motif Chemokine Ligand 1 Sustains Breast Cancer Stem Cell Self-Renewal and Promotes Tumor Progression and Immune Escape ProgramsSemantic proximity Read ↗

Long noncoding RNA DLEU2 and ROR1 pathway induces epithelial-to-mesenchymal transition and cancer stem cells in breast cancerSemantic proximity Read ↗

DDX5 Regulates DNA Replication and Is Required for Cell Proliferation in a Subset of Breast Cancer CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.