Article

Targeting UBR5 inhibits postsurgical breast cancer lung metastases mediated by CDC73 and p53

2022-12-21

Abstract excerpt

<title>Abstract</title> <p>UBR5 is a HECT domain E3 ubiquitin ligase that is frequently amplified in breast, ovarian, and prostate cancers. Heightened UBR5 plays an oncogenic role in promoting tumor growth through immune-dependent mechanisms. However, its mode of action in driving tumor metastasis has not been definitively delineated. In this study, we used a tetracycline (Tet)-inducible RNAi-mediated expression...

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Literature Corpus work: d391fd53-abbe-56d6-bd1b-fa1a870e0b31
DOI: 10.21203/rs.3.rs-2378704/v1

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