Article

WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation

2022-03-30

Abstract excerpt

Metastatic breast cancer remains a major cause of cancer related deaths in women and there are few effective therapies against this advanced disease. Emerging evidence suggests that key steps of tumor progression and metastasis are controlled by reversible epigenetic mechanisms. Using an in vivo genetic screen, we identified WDR5 as an actionable epigenetic regulator that is required for metastatic progression in...

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Literature Corpus work: 565c252d-d6c6-540b-9577-17d9c5a3eb33
DOI: 10.1101/2022.03.30.486357

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