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Cullin5 deficiency promotes small-cell lung cancer metastasis by stabilizing integrin β1

27 Jan 2019

Abstract excerpt

Metastasis is the dominant cause of patient death in small-cell lung cancer (SCLC), and a better understanding of the molecular mechanisms underlying SCLC metastasis may potentially improve clinical treatment. Through genome-scale screening for key regulators of mouse Rb1-/- Trp53-/- SCLC metastasis using the pooled CRISPR/Cas9 library, we identified Cullin5 (CUL5) and suppressor of cytokine signaling 3 (SOCS3),...

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PMID: 30688657
DOI: 10.1172/jci122779

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