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Article

HDHD5 promotes triple-negative breast cancer growth and drives EMT-associated phenotypes via regulating S100A4.

Journal of cancer research and clinical oncology - 29 Apr 2026

Cai Jia-Yang, Zhang Yin-Ling, Zhang Fang-Lin, Zhao Qian, Ma Meng-Ke, Shao Zhi-Min

Abstract excerpt

PURPOSE: Triple-negative breast cancer (TNBC) displays an aggressive clinicopathological profile. Despite cytotoxic chemotherapy being the primary systemic therapy, complete responses are achieved in fewer than 30% of patients, highlighting the need for new therapeutic targets and a deeper understanding of disease-driving mechanisms. METHODS: This study identified key oncogenic factors in TNBC through multi-omics...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42056314
DOI: 10.1007/s00432-026-06477-x
PMCID: PMC13129178

Genes

HDHD5
S100A4
CCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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