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A linear ontogeny accounts for the development of naive, memory and tumour-infiltrating regulatory T cells in mice

2024-07-16

Abstract excerpt

Foxp3 + Regulatory T cells (Treg) are a subset of CD4 + T cells that play critical functions in maintaining tolerance to self antigens and suppressing autoimmunity, regulating immune responses to pathogens and have a role in the pathophysiology of anti-tumoural immunity. Treg ontogeny is complex since they are generated following recognition of self antigens in the thymus during normal T cell development (thymic...

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Identifiers and source

Literature Corpus work
4d117496-e91f-5a4e-9a79-22689941a9c9
DOI
10.1101/2024.07.10.602914
Open publication

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A linear ontogeny accounts for the development of naive, memory and tumour-infiltrating regulatory T cells in miceDOI 10.1101/2024.07.10.602914
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