Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulatory T-Cell Development in the Human Thymus

3 Aug 2015

Abstract excerpt

The thymus generates a lineage-committed subset of regulatory T-cells (Tregs), best identified by the expression of the transcription factor FOXP3. The development of thymus-derived Tregs is known to require high-avidity interaction with MHC-self peptides leading to the generation of self-reactive Tregs fundamental for the maintenance of self-tolerance. Notwithstanding their crucial role in the control of immune...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenal Hormones and Disorders
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26284077
DOI: 10.3389/fimmu.2015.00395

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulatory T-Cell Development in the Human ThymusPMID 26284077Read ↗

Immune tolerance and the prevention of autoimmune diseases essentially depend on thymic tissue homeostasisSemantic proximity Read ↗

Thymic Epithelial CellsSemantic proximity Read ↗

Beyond FOXP3: a 20-year journey unravelling human regulatory T-cell heterogeneity.Semantic proximity Read ↗

The role of T-cell receptor recognition of peptide:MHC complexes in the formation and activity of Foxp3⁺ regulatory T cells.Semantic proximity Read ↗

Regulatory T cells: a review.Semantic proximity Read ↗

Ontogeny of CD4+CD25+ regulatory/suppressor T cells in human fetuses.Semantic proximity Read ↗

Delineating phenotypic heterogeneity in human regulatory T cells across developmental stages and therapeutic sources.Semantic proximity Read ↗

Development and function of Foxp3(+) regulatory T cells.Semantic proximity Read ↗

Regulatory T cells and their roles in immune dysregulation and allergy.Semantic proximity Read ↗

Past, Present, and Future of Regulatory T Cell Therapy in Transplantation and AutoimmunitySemantic proximity Read ↗

The importance of regulatory T-cell heterogeneity in maintaining self-tolerance.Semantic proximity Read ↗

Functional development of γδ T cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.