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Article

New insights on T-cell self-tolerance.

Current opinion in immunology - 1 Apr 2020

Yi Jaeu, Kawabe Takeshi, Sprent Jonathan

Abstract excerpt

Self-tolerance of T cells is maintained by a combination of thymic negative selection and suppression by T regulatory cells (Tregs); both processes are driven by recognition of self MHC ligands. Treg function ensures that most T cells remain quiescent as naïve cells, but enables some T cells to proliferate and differentiate into cells with a memory phenotype (MP). In this review, we discuss how Tregs shape this...

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Identifiers

PMID: 31786417
DOI: 10.1016/j.coi.2019.10.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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